Description
ICAM-5, also known as telencephalin, is a cell surface glycoprotein belonging to the immunoglobulin superfamily. Human ICAM-5 is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. The tissue of ICAM-5, being expressed only in telencephalic regions of the central nervous system. Like other ICAMs, ICAM-5 binds to the leukocyte integrin LFA-1. Recombinant human ICAM-5, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques